Living longer lives has always been a desire of humanity. But, unfortunately, the older we get, the more our health declines during those added years. So, when talking about longevity, the focus is not only on extending the lifespan; it is much more about expanding the number of healthy years. This healthspan represents the years in which we are in good health and disease-free. Looking at some numbers, for example, from Western Europe: the average lifespan is 80 years, while the average healthspan is only 65 years. Is this not shocking that we spend up to 20% of our lives in poor health? However, studies have shown that by following a healthy lifestyle and supporting new technologies such as wearables or supplements, we can make a change.
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The Science of Longevity
Longevity research is one of the most rapidly advancing fields in aging science. Out of this, supplements are one of the focus areas. Unlike most other supplements focusing on preventing deficiencies, longevity supplements supply the body with ingredients that help change the rate at which we age.
Maybe one day you are relaxing by the pool and thinking about the healthspan of your life. That long healthy life is what you are after. No worries, you are not alone, and there are already solutions. This guide shares all about NMN for aging and longevity.
NMN stands for nicotinamide mononucleotide and is a naturally-occurring compound that has been found to have various effects on aging and longevity. This is because it has been shown to help with apoptosis and Autophagy, two fundamental processes in the body’s ability to age.
Apoptosis is the process by which cells die off when they are no longer needed. Autophagy is how your body gets rid of old cells and other waste products. The best way to explain it is like this: cells can be thought of as little factories producing new cells to replace damaged ones. If those factories do not get enough raw materials, people will eventually start noticing severe side effects – like wrinkles or gray hair!
NMN helps ensure that these factories run smoothly by providing them with all the necessary raw materials. It also helps keep your body from producing too many dead cells. This means less damage from sun exposure, less damage from free radicals, and fewer wrinkles!
Suppose you are a fan of dermatology and, specifically, you are into aging and longevity innovations. In that case, you may have heard of NMN already. It naturally occurs in our bodies, but some people have started taking it as a supplement. Scientists of renowned universities are looking deep into its potential and promising benefits in several areas of life, for example;
What is NMN?
NMN is a precursor of NAD+, which stands for nicotinamide adenine dinucleotide, a coenzyme present in cells of our body. NMN is a natural derivative of Vitamin B3. By keeping it easier to understand: NMN is a naturally occurring molecule that powers our body. It is a type of nucleotide. Nucleotide performs numerous functions in our bodies. Some of their tasks are written below;
Involves in metabolism
Building blocks of DNA
NMN is a raw material, and NAD+ is a refined version. Therefore, the production of NAD+ in our bodies directly depends on the availability of NMN in our bodies. NAD+ is used by all cells in your body and thus requires NMN, its precursor, to function properly. NAD+ assists cells in regulating a variety of essential functions that keep your cells running smoothly, such as:
Cellular stress response
It is necessary to have optimal levels of NMN in your body to perform optimal functions. Unfortunately, as you probably can tell by now, the level of NMN declines as we age. And so your levels of NAD+ will also decline with the increase of your age.
Potential Benefits of NMN
NMN is a precursor to NAD+, a vital compound for energy production, anti-aging, and DNA repair. Unfortunately, NAD+ declines with age, and not eating enough calories can lead to low energy levels and even chronic diseases like cancer. Strong experimental evidence shows that the deregulation of microRNAs (miRNAs) has a role in vascular aging.
NMN boosts your metabolism by increasing the rate at which your cells use glucose (the main source of fuel) while also protecting them against oxidative stress caused by free radicals in the body. In addition, NMN supplements help support healthy aging by helping you stay energized throughout the day to get things done!
Restore NAD+ Levels, which decline with Age
NAD+ is a naturally occurring molecule that helps maintain body energy levels. With age, the decline in NAD+ levels has been correlated with many health problems, including cancer and cardiovascular disease. In a study published in Nature Communications (2015), scientists used a highly purified extract of green tea leaves to restore NAD+ levels in mice and fruit flies. They found that this treatment increased lifespan by 20%. NMN has also been shown to have anti-inflammatory effects, which could be one of the reasons it can help with some of the physical effects associated with aging.
Numerous studies have shown that NMN can help prevent or slow the aging process, which is extremely important for people who are looking to extend their healthspan. In fact, a recent study published in the “Journal of Medicinal Food” found that NMN may help prevent age-related diseases like Alzheimer’s and Parkinson’s disease.
Additionally, NMN has been shown to help with weight loss and improve energy levels. This makes NMN a great supplement choice for anyone looking to lose weight or boost their energy levels. Knowing that it can also help reduce inflammation in the body makes it an even more attractive option for people who suffer from chronic pain or other ailments caused by inflammation.
250mg of NMN per Day for Longevity
As you get older, your levels of NAD+ decline. As a result, your energy level and appetite for adventure differ from your 20s. However, NMN can help restore some of it.
Avea Life is a company from Switzerland on a mission to become the leading player in the evidence-based longevity supplement industry. Using their supplements counteracts the effects of aging. One bottle contains 30 capsules (250mg) of Nicotinamide Mononucleotide (NMN) and lasts for one month. The regular cost is $49, and they are shipping internationally. With the code “TRYAVEA15” you can secure a 15% discount. And they even offer a 30-day money-back guarantee.
However, more than taking supplements is required. This is a journey to a healthy lifestyle and also requires some work. For some, intermediate fasting of 16 hours, three-four times per week, was a good add-on; others have been very successful by cutting out sugar, and others love the high-intensity workouts. Do not underestimate the importance of sleep to get the best results. And last but not least, this is not about black/white. The goal of longevity should be to enjoy life and to have fun as long as possible.
This introduction has given you a better understanding of Nicotinamide Mononucleotide (NMN) ‘s benefits and why it is such a popular supplement among those who want to live longer healthier lives. We have also covered some important details about how NMN works in your body and what other health benefits might arise from taking it daily. So what else can you do? Get yourself a hotel that supports your lifestyle and grants you access to a great fitness center. You can find all of them on HotelGyms.com.
Kiss, T., Giles, C.B., Tarantini, S. et al. Nicotinamide mononucleotide (NMN) supplementation promotes anti-aging miRNA expression profile in the aorta of aged mice, predicting epigenetic rejuvenation and anti-atherogenic effects. GeroScience 41, 419-439 (2019).
Marjan Talebi, Eleni Kakouri, Mohsen Talebi, Petros A. Tarantilis, Tahereh Farkhondeh, Selen ?lg?n, Ali Mohammad Pourbagher-Shahri, Saeed Samarghandian. (2021) Nutraceuticals-based therapeutic approach: recent advances to combat pathogenesis of Alzheimer’s disease. Expert Review of Neurotherapeutics 21:6, pages 625-642.